Scientist Job GAP Solutions Inc Bethesda

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GAP Solutions, Inc. Hiring 2020 - GAP Solutions, Inc. offer an opportunity to apply Scientist that will be placed in Bethesda.

GAP Solutions, Inc. Recruitment 2020

Description :

Provide services as a Scientist in support of the overall functions of the Vaccine Research Center (VRC), Structural Biology Section (SBS) within the National Institute of Allergy and Infectious Diseases (NIAID).


Duties and Responsibilities:

  • Serve as a Scientist for the Structural Biology Section of the Vaccine Research Center (VRC) specifically, to lead coordination of cryo-electron microscopy (cryo-EM) projects for the VRC.
  • Coordinate cryo-EM data collection on vaccine targets including:

o SARS-CoV-2 spike

o Human Immunodeficiency Virus-1 (HIV-1)

o Influenza

o Malaria

o Human metapneumovirus (HMPV)

o Simian-human immunodeficiency virus (SHIV)

o Human cytomegalovirus (HCMV)

o Norovirus

o Simian Immunodeficiency virus

o Lassa virus

  • Optimize sample vitrification conditions and collect high magnification data, at approximately one angstrom per pixel, on various viruses related to ongoing or upcoming VRC clinical trials such as HIV-1 fusion peptide-directed neutralizing antibodies, HIV-1 broadly neutralizing antibody candidates for passive immunization, and antibodies elicited by universal influenza vaccine candidates.
  • Expand the breadth and capability of HIV-1 projects by increasing the number of HIV-1 envelope trimer strains.
  • Advance the quality of data acquisition to obtain datasets at resolutions better than 4.0Å, in some cases better than 3.5Å and rare cases better than 3.0Å.
  • Analyze cryo-EM data collections including frame alignment, contrast transfer function estimation, particle picking through neural network algorithms, 2D classification, 3D ab-initio reconstructions, 3D classification through heterogeneous refinement, homogeneous refinement, masked local refinement, particle polishing, and 3D variability.
  • Provide scientific expertise to cross-group project teams to inform on recent advances and offer constructive critiques on experiment proposals in order to facilitate vaccine design.
  • Train students, postdocs, and staff scientists of the SBS in cryoEM data processing using various state-of-the-art software for 3D reconstructions and atomic model building. Review various algorithms in training to contrast stochastic gradient descent with maximum likelihood optimizations to enhance data processing options for difficult datasets.
  • Train students and postdocs of collaborating groups including a lab in New York in all aspects of cryo-EM, including consultation and hands-on facilitation for the startup of COVID-19 projects.
  • Publish the findings from experiments listed above in peer-reviewed journals and present at scientific conferences.
  • Coordinate deposit of experimentally determined data and atomic level models in public databases such as the Protein Data Bank and the Electron Microscopy Data Bank.

Basic Qualifications:

  • This support position requires a minimum of Ph.D. with specific training in cryo-EM and at least 5-year postdoctoral experience in structural biology.
  • Candidate should be familiar with standard EM sample preparation protocols including negative staining and plunge freezing.
  • Experience with operation KRIOS microscopes or similar.
  • Experience with common cryo-EM software packages for collecting and processing data such as Leginon, Relion, cryoSPARC, and EMAN2.
  • Experience with software for model building and refinement such as Phenix, ccp4-em, Chimera, Rosetta, and Isolde.
  • Capable with establishing a database for project and data tracking and organizing large computational resources for processing and storage of approximately a petabyte of data.

Minimum Qualifications:

  • Ability to communicate effectively, orally and in writing, with non-technical and technical staff
  • Detail-oriented and possess strong organizational skills with the ability to prioritize multiple tasks and projects

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


  • This job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required by this position.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.


GAP Solutions provides reasonable accommodations to qualified individuals with disabilities. If you need an accommodation to apply for a job us at [email protected] You will need to reference the requisition number of the position in which you are interested. Your message will be routed to the appropriate recruiter who will assist you. Please note, this email address is only to be used for those individuals who need an accommodation to apply for a job. Emails for any other reason or those that do not include a requisition number will not be returned.



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